Abstract
Mice rather than rats [1-3] were employed in screening studies designed to define agents effective in protecting the gastric mucosa from the damaging effects of reserpine (RP); this approach allowed utilization of smaller quantities of the agents in question. The purpose of this study was to compare the antiulcerogenic efficacy of monoamine oxidase (~AO) inhibitors (iproniazid, Niamid, pargyline, phenylzin [4, 5]), m-cholinoblockers (atropine sulfate, metamizil HCI, and their iodomethylates), the catechol-o-methyltransferase (COMT) inhibitor depaverin [6], the adrenomimetic ephedrine and the centrally acting secretagogue 2-deoxy-D-glucose in reserpine-induced gastric ulcers in mice. Selection of the drugs was based on the observation that MAO inhibitors exerted a protective effect on reserpine-treated rats [7-9], ~lile the m-cholinolytics (atropine, metamizil) appeared to be ineffective in the prevention of RPinduced gastric lesions [9]. However, individual communications report on the antiulcerogenic effects of iproniazidand atropine in mice [i0]. Using the method developed by us for evaluating the ulcerogenicity of RP, we determined to uncover the most potent antiulcer agents from each group and compare them for their effectiveness on our RP ulcer model in the mouse.
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