Abstract
<p><strong>Background:</strong> Dry eye is a serious problem affecting up to 20% of the world’s population. <em>Mondia whitei</em>’s rich androgenic properties create an interest in research focused on its efficacy as an alternative and complementary therapy for the treatment and control of the symptoms of dry eye-related diseases associated with androgen deficiency. <strong>Aim: </strong>This study aimed to investigate the effect of <em>M. whitei</em> on the quality and quantity of tears in rabbit eyes.<strong> Setting: </strong>This study was carried out at the animal house at Masinde Muliro University of Science and Technology, Kakamega, Kenya. <strong>Materials and methods:</strong> The study adopted an experimental study design with 16 New Zealand rabbits. A simple random sampling technique was used to place the rabbits into 4 groups, each group with 4 rabbits. They were tested for tear function to establish a baseline before administration of Benzalkonium Chloride (BAC) (to induce dry eye) and <em>M. whitei</em> extract. Schirmer’s test and fluorescein staining were conducted to observe the tear quantity and quality over a period of 6 days after treatment. The data collected was then cleaned and analyzed. <strong>Results:</strong> The researchers found that the average mean during baseline tear quantity measurement for the groups was 26.5mm, during instilling of BAC the mean dropped to 24.0mm and when <em>M. whitei</em> was administered the mean rose to 27.94mm, indicating that <em>M. whitei</em> greatly improved tear quantity. During baseline tear quality assessment, the average mean for the groups was 0.00 which dropped to 0.94 showing mild staining and when <em>M. whitei</em> was administered dropped further to 1.67 indicating that <em>M. whitei</em> did not improve the tear quality. <strong>Conclusion and Recommendations:</strong> The researchers recommended that more research be done on <em>M. whitei </em>with fewer limitations such as time, to ascertain its effectiveness on tear quality and quantity.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0065/a.php" alt="Hit counter" /></p>
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