Effects of moderate and high intensity endurance trainings on INFγ and TNFα of Streptozotocin induced diabetic rats

Abstract

Diabetes is an inflammatory autoimmune disease that results in insulin deficiency and hyperglycemia.The purpose of this study was to investigate and compare the effects of endurance training with moderate and high intensity on INFγ and TNFα in diabetic rats. In this experimental study, 32 diabetic rats were induced with Streptozotocin and placed into four groups of eight, including: (1) control of the first week, (2) control of the last week, (3) moderate endurance training, and (4) high intensity endurance training. Rats in incremental endurance training group with moderate intensity (10 minutes at 10 m / min in the first week and 45 minutes at 17 m / min in the eighth week), and in high intensive endurance training group (10 minutes at speed 17 m / minute in the first week and 45 minutes at a speed of 28 m / minute in the eighth week) for 8 weeks, 3 sessions per week ran on a treadmill. To analyze the data, statistical tests of Kalmogorov-Smirnov, independent t-test, Pearson correlation coefficient and one-way ANOVA with Tukey's post hoc test were used (p≤0.05). Results showed that eight weeks of time in Streptozotocin-induced diabetic rats caused a significant increase in serum levels of INF-γ (p = 0.001) and TNF-α (p = 0.01); eight weeks of endurance training with moderate intensity had a significant effect on reduction of INFγ (p = 0.004) and TNFα (p = 0.005); eight weeks of high intensity endurance training had a significant effect on TNFα decrease (0.001) 0 = p). However, there was no significant effect on decreasing INFγ (p = 0.09). Also, eight weeks of endurance training with moderate and high intensity had the same effect on the reduction of serum levels of INFγ (p = 0.33) and TNFα (94 / 0 = p). In Streptozotocin-induced diabetic rats, after eight weeks of high intensity endurance training, there was a significant positive correlation between serum levels of INFγ and TNFα (p = 0.02). However, after eight weeks of endurance training with moderate intensity, no significant relationship existed (p = 0.47). Accordingly, it seems that endurance trainings with moderate and high intensity had the same effect on decreasing INFγ and TNFα in diabetic rats with Streptozotocin.