Abstract
AbstractEffect of mixing time on the flowability, compressibility, tablet hardness and dissolution of theophylline tablets was investigated using two types of mixers, i.e., twin-shell and high-speed mixers. Theophylline, three kinds of lactose ($aL-monohydrate, β-anhydrate and spray-dried product), disintegrator and magnesium stearate were mixed, and tablets were compressed. While the particles mixed with magnesium stearate by the high speed mixer were coated with magnesium stearate, those mixed by the twin-shell mixer formed an ordered mixture. The dissolution differed depending on the mixing time and method.
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