Abstract
Mirabegron is the first b3-adrenoceptor agonist to enter clinical practice and has been approved for the treatment of symptoms of OAB. The aim of this study is to investigate whether the mirabegron has an effect on depression, anxiety, learning, and memory. We investigated the effects of mirabegron on depression, anxiety, learning and memory by using forced swimming test, elevated plus maze test, passive avoidance and Morris water maze in mice. Imipramine and mirabegron (3, 6 and 9 mg/kg) significantly reduced immobility time in forced swimming test. Diazepam and mirabegron (3, 6 and 9 mg/kg) significantly increased the time spent in open arms and the number of entries to the open arms in elevated plus maze test. Furthermore, cognitive performance impaired with scopolamine has been significantly improved with 9 mg/kg mirabegron. Mirabegron (6 and 9 mg/kg) significantly increased the time spent in the target quadrant in naive mice. While scopolamine significantly increased the swimming speed, mirabegron (9 mg/kg) significantly decreased the swimming speed in scopolamine-treated mice. Mirabegron might be clinically useful for the treatment of OAB in elderly patients that should use drugs against depression and anxiety, without disrupt learning and memory.
Highlights
Overactive bladder (OAB) is a condition that is characterized by involuntary contraction of the muscle in the wall of the urinary bladder
Experimental Design We investigated the effects of mirabegron on depression, anxiety, learning and memory by
One-way analysis of variance (ANOVA) showed a significant effect of mirabegron and imipramine treatment upon immobility time in Forced swimming test (FST) [F (4.44)=55,650, p
Summary
Overactive bladder (OAB) is a condition that is characterized by involuntary contraction of the muscle in the wall of the urinary bladder. The exact cause of these contractions is often not known. Millions of people around the world are affected from this and struggle with OAB symptoms. Patients with OAB may feel embarrassed, isolate themselves, or limit their work and social life. Anxiety, depression, sleep disturbances and issues with sexuality, OAB can affect their life qualities (Lee et al 2015, Coyne et al 2004). Depression and anxiety are associated with OAB and their levels are mainly related with urgency incontinence and nocturia (Melotti et al 2018)
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