Abstract
BackgroundThe effects of performing a minimally invasive procedure at different stages after intracerebral hemorrhage on perihematomal MMP-9 expression and blood–brain barrier (BBB) permeability were evaluated.MethodsSixty rabbits were randomly distributed into a model control group (MC group, 30 rabbits) or a minimally invasive group (MI group, 30 rabbits). A model of intracerebral hemorrhage was established in the MC and MI group. In the MI group, the intracerebral hematoma was evacuated by stereotactic minimally invasive procedures over 6 hours (6 rabbits), 12 hours (6 rabbits), 18 hours (6 rabbits) 24 hours or 48 hours (6 rabbits) following successful induction of intracerebral hemorrhage. The same procedure was performed in the MC group at the same time point but without evacuating the hematoma. All the animals were sacrificed within two weeks after the hematoma was surgically evacuated. A neurological deficit score was determined, and the perihematomal MMP-9 level and the BBB permeability were measured.ResultsThe neurological deficit score, perihematomal MMP-9 level and BBB permeability of the MI group decreased significantly compared to the MC group. Performing the MI procedure 6–12 h after intracerebral hemorrhage showed the most favorable outcome.ConclusionsRegarding the pathophysiological changes surrounding the hematoma, the optimal time window of performing MI procedures for the intracerebral hematoma evacuation might be within 6–12 h after hemorrhage.
Highlights
The effects of performing a minimally invasive procedure at different stages after intracerebral hemorrhage on perihematomal Matrix metalloproteinases (MMPs)-9 expression and blood–brain barrier (BBB) permeability were evaluated
As the time window prolonged, Evans blue and water content increased and reached their peak in the 48 h MI group. These results suggested that evacuating the intracerebral hematoma by performing MI procedures within 48 hours after the onset of hemorrhage could reduce the perihematomal permeability of BBB and decrease cerebral edema
The results showed that perihematomal MMP-9 significantly decreased after surgery within different time windows for the evacuation of intracerebral hematoma as compared with the MC group
Summary
The effects of performing a minimally invasive procedure at different stages after intracerebral hemorrhage on perihematomal MMP-9 expression and blood–brain barrier (BBB) permeability were evaluated. Spontaneous intracerebral hemorrhage (ICH) remains the least treatable form of stroke. It is associated with high rates of morbidity and mortality. The minimally invasive stereotactic puncture and thrombolysis therapy has displayed favorable outcomes, the effect of such procedure for ICH evacuation on perihematomal brain tissues remains elusive. The early stage (within 7–24 h) was found to be the optimal time-window for surgical intervention of spontaneous ICH [12]. These results are based on clinical observations. The selected indices could not reflect the perihematomal pathophysiological changes
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
