Abstract
Isolated rat liver mitochondria were exposed to continuous (cw) millimeter wave irradiation and evaluated for changes in phosphorylation of ADP and Ca/sup 2 +/ uptake and efflux. Exposures at 25/sup 0/C at 34.92 GHz at power densities of 500 and 1000 mW/cm/sup 2/ resulted in losses of respiratory control, decreases in levels of Ca/sup 2 +/ uptake, and increases in extents of Ca/sup 2 +/ efflux. These changes were drastically reduced if the temperature of the exposure chamber was maintained at 4/sup 0/C during the irradiation. In addition, loss of respiratory control did not follow a time-dose relationship. Therefore, the loss of energy coupling at high power densities of irradiation was attributed to thermal damage to the mitochondrial membranes. Exposures of mitochondrial suspensions, which were actively phosphorylating ADP, to 34.92-GHz irradiation for 2 min at power densities of up to 1000 mW/cm/sup 2/ and to frequencies between 50 and 60 GHz at 5 mW/cm/sup 2/ had no apparent effect on the levels of ATP synthesis linked to succinate respiration. Similarly, exposures at 34.92 GHz at power densities of 250 mW/cm/sup 2/ or less and exposures between 50 and 60 GHz at 5 mW/cm/sup 2/ had no apparent effect on either more » Ca/sup 2 +/ uptake or efflux. It is concluded that other than damage due to thermal effects, oxidative phosphorylation and Ca/sup 2 +/ transport in rat liver mitochondria are quite insensitive to millimeter wave irradiation at the frequencies, power densities, and intervals of exposures used in these studies. « less
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