Abstract
Vitamin deficiency, bacterial overgrowth, and gastrointestinal symptoms can be detected in obese patients after bariatric surgery that influences their quality of life (QoL) and weight. It is unclear if microecological preparations benefit obese patients following bariatric surgery. The aim of this study is to investigate the effects of microecological preparations on QoL, excess weight loss (EWL), and levels of vitamin B12 and inflammatory markers. We searched seven databases to identify reports published till December 1, 2019, and included randomized controlled trials investigating the effects of microecological preparations in obese adults undergoing bariatric surgery. The primary outcomes included QoL and EWL, while secondary outcomes comprised serum levels of vitamin B12, interleukin 6, TNF-α, and C-reactive protein (CRP). Study bias was analyzed using the Cochrane risk-of-bias tool. Statistical analyses were performed using Review Manager. The mean difference in outcomes was calculated using standardized mean difference (SMD) with a confidence interval (CI) of 95%. A majority of the studies showed a low or moderate risk of bias. Meta-analysis showed significantly higher levels of vitamin B12 in postoperative patients administered with microecological preparations (SMD = 0.52; 95% CI = 0.08–0.95; P = 0.02). There were no significant differences in QoL (SMD = −0.14; 95% CI = −0.45–0.17; P = 0.38), EWL (SMD = 0.45; 95% CI = −0.16–1.05; P = 0.15), and levels of TNF-α (SMD = −0.29; 95% CI = −0.64–0.05; P = 0.09), interleukin 6 (SMD = −0.1; 95% CI = −0.81–0.61; P = 0.78]), and CRP (SMD = 0.02; 95% CI = −0.32–0.36; P = 0.93). The trials examined indicated that microecological preparations had limited efficacy in improving QoL, EWL, and inflammatory response, but they stimulated the synthesis of vitamin B12. This may help in designing efficient microecological preparations to supplement bariatric surgery in obese individuals.
Highlights
Obesity is a global health concern associated with physical and psychological conditions that present challenges for the healthcare industry. e World Health Organization has reported that more than 39% and 13% of adults were overweight and obese, respectively, in 2016 [1]
Bacterial overgrowth, and gastrointestinal symptoms can be detected in obese patients after bariatric surgery that influences their quality of life (QoL) and weight. It is unclear if microecological preparations benefit obese patients following bariatric surgery. e aim of this study is to investigate the effects of microecological preparations on QoL, excess weight loss (EWL), and levels of vitamin B12 and inflammatory markers
We included obese adults who had undergone bariatric surgery. e experimental group was treated with microecological preparations. e control group was subjected to placebo or conventional treatment. e primary outcomes comprised QoL and EWL. e secondary outcomes included vitamin B12 and inflammatory markers, such as C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α)
Summary
Obesity is a global health concern associated with physical and psychological conditions that present challenges for the healthcare industry. e World Health Organization has reported that more than 39% and 13% of adults were overweight and obese, respectively, in 2016 [1]. E World Health Organization has reported that more than 39% and 13% of adults were overweight and obese, respectively, in 2016 [1]. Obesity is a socioeconomic burden that is associated with increased medical costs for the treatment of related diseases [6]. Bariatric surgery is currently used as the most effective and reliable method to treat morbid obesity and comorbidities [7]. Bariatric surgery reduces the abundance of gut Evidence-Based Complementary and Alternative Medicine microbiota and triggers changes in microbial composition. Patients who have undergone bariatric surgery are associated with modifications in the composition of gut microbiota that result in vitamin deficiency, bacterial overgrowth, and gastrointestinal disorders, thereby influencing postoperative clinical outcomes [10]
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