Abstract
Vitamin B 1- and B-deficient encephalopathy was produced in adult Wistar rats and the effect of methylcobalamin was studied. These experiments were performed in vitamin B 1- or B-deficient rats with or without the administration of guanidine, a magnesium antagonist. These encephalopathic rats showed symmetrical lesions in the pontine tegmentum. No pathological changes in the brainstem were seen in guanidine-administered rats. This suggests that guanidine itself doesn't produce these brainstem lesions. Moderate to severe pathological changes occurred in vitamin B-deficient rats with guanidine administration, whereas these pathological changes were milder in vitamin B 1-deficient rats with guanidine administration and in vitamin B 1- and B-deficient rats with the combination of the guanidine and methylcobalamin administrations. These facts suggest that vitamin B 12, methylcobalamin, plays an important preventive role in the development of the pontine lesions in this experiment.
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