Abstract
We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin 2 (5-HT 2) receptors, and also whether metaphit decreases the capacity of 5-HT 2 receptors. Metaphit ( 1 μ mol rat ) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT 2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy- N, N-dimethyltryptamine-induced 5-HT 1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT 2 receptors may have very similar binding sites.
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