Abstract
The effects of methylmercuric chloride, mercuric chloride, and phenylmercuric acetate (10 −6–10 −3 mole/liter) on thrombin-induced release of adenine nucleotides from washed pig platelets were investigated. The inhibitory effects of mercurials were always reached when the higher thrombin concentration (0.74 units NIH/ml) was used. Incubation of washed pig platelets with methylmercuric chloride caused a decrease of intracellular level of platelet ATP and statistically significant changes in ATP ADP ratio.
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