Effects of menopause and fat mass in asthmatic inflammation

Abstract

Introduction Female hormones and obesity have an impact on women with asthma. We aimed to describe how these components affect asthma inflammatory processes. Methods Sex hormones [FSH, LH, estradiol (E2), estrone (E1), testosterone and Δ4 androstenedione (A4)] and serum IL1β, IL13, IL17a, IL-5, IL6, TNF-a were measured from 11 to18 pre- and postmenopausal women with asthma. Results Premenopausal normal weight women revealed higher levels of IL5 and IL17a than obese women on both days of the menstrual cycle (IL5: D1: 6.4 vs 1.4 pg/ml, p = .036 and D14: 3 vs 1.4 pg/ml, p = .045 and IL17a: D1: 13.7 pg/ml vs 10.6 pg/ml and D14: 12.4 pg/ml vs 10.6 pg/ml, p = .009, respectively). In premenopausal women on D1, Δ4 Androstenedione was positively correlated with IL1β (p = .016, r = 0.733), whereas on D14, Estradiol with IL1β (p = .009, r = −.768) and TNF-a with Testosterone (p = .004, r = −0.816), and Δ4 Androstenedione (p = .002, r = −0.841) negatively. In postmenopausal women, TNF-a was negatively associated with FSH (p = .004, r = −0.638), but positively with Testosterone (p = .025, r = 0.526) and IL10 also positively with Estradiol (p = .007, r = 0.610). Conclusion Obesity shows a protective role in asthma through the suppression of IL5 and IL17. Estrogens seem to inhibit Th1 and Th2 inflammation, while androgens have a dual role with negative and positive correlations with neutrophilic biomarkers.