Abstract
Aim:This study aimed to evaluate the effects of Meniran extract (Phyllanthus niruri L.) administration on leukocyte profile of broiler chickens infected with Mycoplasma gallisepticum.Materials and Methods:Thirty broiler chickens, 21 days old were divided into five treatment groups. P0 (−): Chickens without any treatment; P0 (+), P1, P2, and P3: Chickens were infected with M. gallisepticum 108 cells/ml/animal orally, then given no treatment, Meniran extract 60%, 62.5%, and 65% orally at a dose of 1 ml/kg body weight, respectively. The treatment of Meniran extract was given for 7 days.Results:Leukocyte count with the lowest number showed in Group P0 (−) and Group P3 (p>0.05). Increased number of basophils was found in Group P0 (+), Group P1, and Group P2. The highest number of heterophils was found in Group P0 (+) and was significantly different from Group P0 to P3 (p<0.05). The same pattern was also seen in the number of lymphocytes in all treatment groups. The number of monocytes showed no significant difference between all treatment groups (p>0.05).Discussion:Increased the number of leukocytes is often observed in inflammation due to general infections, trauma, or toxicity. Shifting in the number of heterophile or lymphocytes, an increase in the number of monocytes, basophils, and eosinophils may also be associated with various infectious or inflammatory conditions. Heterophils play a role as an antibacterial defense through several effective mechanisms. When infections and inflammation occur, the heterophils will increase to phagocytosis microbe.Conclusion:It can be concluded that Meniran extract (P. niruri L.) at a dose of 65% can decrease the total number of leukocytes in broilers infected with M. gallisepticum.
Highlights
Endemic disease that attacks broiler chicken farms is considered as one of the obstacles of broiler chicken business since it will cause huge economic losses
P0 (−): Chickens without any treatment; P0 (+), P1, P2, and P3: Chickens were infected with M. gallisepticum 108 cells/ml/animal orally, given no treatment, Meniran extract 60%, 62.5%, and 65% orally at a dose of 1 ml/kg body weight, respectively
It can be concluded that Meniran extract (P. niruri L.) at a dose of 65% can decrease the total number of leukocytes in broilers infected with M. gallisepticum
Summary
Endemic disease that attacks broiler chicken farms is considered as one of the obstacles of broiler chicken business since it will cause huge economic losses. One of the diseases that can lead to huge economic losses for broiler chicken farms is respiratory disease [1]. Bacterial infection appears to play the greatest role. One of the bacteria capable of causing respiratory disease in broiler chickens is Mycoplasma gallisepticum, known as the cause of chronic respiratory disease (CRD) [2]. M. gallisepticum is not an invasive bacterium, but it can spread through the gaps of the respiratory organ cells due to their small size and through blood capillaries [3] by hemorrhaging erythrocytes [4].
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