Effects of Meningic Extract on Testicular Torsion/Detorsion

Abstract

Introduction: Testicular torsion leads to impaired blood supply to the testicles and ischaemia. The incidence is higher especially in newborns and adolescents. As in the treatment of many diseases, various plant combinations are used to prevent the damage caused by testicular torsion-detorsion. In this study, we aimed to investigate the protective effect of meningic (Pistacia terebinthus L.) extract on testicular torsion-detorsion (T/D) injury histopathologically.
 Materials and Methods: The 24 animals used in our experiment were randomly divided into 3 groups. Testicular tissues were stained with hematoxylin-eosin and PAS stains to evaluate histological changes. Modified Johnsen scoring was then performed.
 Results: In the sham group sections, seminiferous tubules were regular and germinal epithelium at various stages of spermatogenesis was seen in 4-5 rows on the basal lamina. In PAS stained sections of the sham group, the basement membrane was regular. In the sections of T/D group, destruction of seminiferous tubules, dilatation and congestion were observed in the vessels in the interstitial area. Thickening of the basal laminae of the seminiferous tubules was also detected in the sections of the T/D group stained with PAS. In the sections of meningic + T/D group, a partial recovery was observed in the seminiferous tubules. The basal lamina thickness in PAS-stained sections of meningic + T/D group was found to be close to normal. According to the results of modified Johnsen score analysis, there was a significant difference between the groups (p<0.05).
 Conclusion: In our study, it was concluded that meningih extract partially protects the testis and its functions.
 Keywords: Testicular injury, torsion, detorsion, meningic extract