Abstract
Abstract: Promazine and imipramine in concentrations between 0.005 mM and 0.20 mM, and thioridazine between 0.005 mM and 0.10 mM inhibit p‐amino‐phenol glucuronidation in rat hepatoma cell cultures. The cardiac stabilizers propranolol and quinidine have little or no effect on glucuronidation. In a homogenate system prepared from the cells promazine, thioridazine, and imipramine between 0.1 and 1.0 mM also inhibit p‐arninophenol glucuronidation. In addition, promazine, thioridazine, and imipramine inhibit alanine uptake/incorporation, α‐aminoisobutyric acid uptake and efflux in the cultures of hepatoma cells.
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