Abstract
Melatonin, a pivotal photoperiodic signal transducer, may work as a brown-fat inducer that regulates energy balance. Our study aimed to investigate the effects of melatonin treatment on the body fat accumulation, lipid profiles, and circulating irisin of rats with high-fat diet-induced obesity (DIO). Methods: 30 male Sprague-Dawley rats were divided into five groups and treated for 8 weeks: vehicle control (VC), positive control (PC), MEL10 (10 mg melatonin/kg body weight (BW)), MEL20 (20 mg/kg BW), and MEL50 (50 mg/kg BW). The vehicle control group was fed a control diet, and the other groups were fed a high-fat and high-calorie diet for 8 weeks to induce obesity before the melatonin treatment began. Melatonin reduced weight gain without affecting the food intake, reduced the serum total cholesterol level, enhanced the fecal cholesterol excretion, and increased the circulating irisin level. Melatonin downregulated the fibronectin type III domain containing 5 (FNDC5) and lipoprotein lipase (LPL) mRNA expressions of inguinal white adipose tissue (iWAT) and induced the browning of iWAT in both the MEL10 and MEL20 groups. Conclusion: Chronic continuous melatonin administration in drinking water reduced weight gain and the serum total cholesterol levels. Additionally, it enhanced the circulating irisin, which promoted brite/beige adipocyte recruitment together with cholesterol excretion and contributed to an anti-obesity effect.
Highlights
Globeisty refers to the worldwide increase in excess weight and obesity according to the WorldHealth Organization (WHO)
In light of the pressing need to check the progression of obesity, our study aimed to investigate the effects of the chronic administration of melatonin on body fat accumulation and lipid profiles
A myokine associated with the browning effect of white adipose tissues (WATs), as a biomarker of brite/beige adipocytes
Summary
Globeisty refers to the worldwide increase in excess weight and obesity according to the WorldHealth Organization (WHO). Globeisty refers to the worldwide increase in excess weight and obesity according to the World. Being overweight and obese are defined as values of the body mass index (BMI), calculated as the weight in kilograms divided by the square of the height in meters, of ≥25 and 30 kg/m2 , respectively. In light of the WHO estimates, over 1.9 billion people were overweight and, of these, over 650 million were obese in 2016—nearly 39% and 13% of the world’s adult population [1]. Obesity results from an imbalance between energy uptake and energy expenditure, and it is considered to increase the incidences of chronic diseases such as cardiovascular diseases, type. Obesity is defined as a condition of abnormal fat accumulation but is recognized as a disease that affects the quality of life and raises the risk of chronic diseases.
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