Effects of medium chain triglyceride on insulin resistance in type 2 diabetes mellitus

Abstract

Objective To observe the effects of medium chain triglyceride(MCT)on insulin resistance in type 2 diabetes mellitus.Methods With long chain triglyceride(LCT)as control,patients were divided into three groups based on their oil intakes:MCT group(100% MCT oil),MCT/LCT group(50% MCT oil+50% LET oil),and LET group(100% LET oil).Oils were taken daily for 3 months.The total energy and fat comumptions were controlled.The blood leveh of fasting plasma glucose(FPG),fasting plasma insulin(FIN),C-peptide(CP),resistin,and beta hydroxybutyric acid(BHBA)at Months 0,1.5,and 3 were measured.The mRNA express of resistin in peripheral blood mononuclear cell was also detected.Afterwards the homeostasis model assessment insulin resistance(HOMA-IR)and the quantitative insulin-sensitivity check index(QUICKI)were analyzed.Results Compared with baseline level,FPG significantly decreased at Month 1.5 in MCT group(P=0.042)and FIN significantly decreased at Month 3 in MCT/LCT group(P=0.005).Compared with LET group,FIN significantly decreased in MCT/LCT group at both Month 1.5 and 3(P=0.033,P=0.006);FIN also significantly decreased in MCT group at Month 1.5(P=0.020).Compared with baseline level,C-peptide significantly increased in MCT group at both Month 1.5 and 3(P＜0.001),and also increased in MCT/LCT group at Month 3(P=0.024).Compared with baseline level,HOMA-IR significantly decreased in MCT/LCT group at Month 3 (P=0.021).Compared with LCT group,HOMA-IB significantly decreased at Month 1.5 in both MCT/LCT and MCT groups(P=0.033,P=0.017).Compared with LCT group,QUICKI significantly increased in MCT/LCT group at Month 3(P=0.011).BHBA was not significantly different at Month 1.5 and 3(P=0.617,P=0.453).Conclusion With total energy and fat consumptions controlled,replacement of 50% dietary oil with MCT can improve insulin resistance. Key words: Medium chain triglyceride; Type 2 diabetes mellitus; Insulin resistance