Effects of medial geniculate lesions on sound localization by the rat.

Abstract

Rats with bilateral lesions of the medial geniculate body were tested on a two-choice sound-localization task that required a directional response to a distant sound source. Stimuli included both broadband and filtered noise bursts presented singly or in repetitive trains. Separate tests were conducted with loudspeakers 180 and 60 degrees apart, centered around 0 degree azimuth. With complete bilateral destruction of the medial geniculate, rats could localize both trains and single bursts of noise and were capable of high levels of performance even at small angles of speaker separation. Some evidence of impaired performance was noted with high-frequency noise bursts, but generally the deficits were not severe. Animals with lesions that extended caudally into the brachium of the inferior colliculus and lateral tegmentum were severely impaired in their ability to localize sounds even at large angles of speaker separation. Three of the four animals in this group were incapable of localizing single bursts even with loudspeakers separated by 180 degrees, and the fourth was unable to perform above chance at 60 degrees. The effects of medial geniculate lesions were very similar to those reported previously for rats with lesions of the auditory cortex, but contrasted with reports of severe impairments in sound localization following damage to the auditory cortex in other mammalian species.