Abstract

 
 
 This reaearch aim was to evaluate some liver enzymes of albino rats subjected to administration of methanol and water extracts of Maytenus senegalensis and Cassia alata after infection with schistosome cercariae. As curative agents, the extracts were well tolerated by rats. The total protein (69.0-77.9g/l and 71.8- 79.1g/l) for methanolic extracts of and (64.3-74.3g/l and 70.3- 77.5g/l) for water extracts for M. senegalensis and C. alata respectively. The Alkaline phosphate values range from (145-226iu/l and 189-207iu/l) for methanol and (143-234iu/l and195-207iu/l) for water as for M. senegalensis and C. alata extracts. The Aspartate aminotransferase values were (7.7-8.7iu/l) for M. senegalensis and (8.0- 8.6iu/l) for C. alata with methanol extraxts and (7.1-8.8iu/l) for M. senegalensis and (8.4-8.9iu/) for C. alata water extracts. The Alkaline aminotransferase values range from (5.1-6.3iu/l) for M. senegalensis and (3.5-6.4iu/l) for C. alata in methanol and (4.2-6.3iu/l) for M. senegalensis and (4.1-6.4iu/l for C. alata with water extracts. The Total Bilirubin values of both methanol and water extracts for M. senegalensis (6.3-18.9μm/l) and (9.0-12.7μm/l) for C. alata and (4.2-6.3μm/l) for M. senegalensis and (4.1-6.4μm/l) for C. alata respectively were all within the normal values. This indicates that all these extracts were well tolerated. However the 9g/kg body weight of the water leaf extracts, although having normal values were toxic to other organs such as the lungs.
 
 
Highlights
This reaearch aim was to evaluate some liver enzymes of albino rats subjected to administration of methanol and water extracts of Maytenus senegalensis and Cassia alata after infection with schistosome cercariae
Total Protein Count: For the roots of Maytenus senegalensis (Table 1), the highest average count in the methanolic extract for the total protein (TPT) was 71.4g/l recorded in rats treated with 3g/kg body weight of the extracts
For the acqueous water extracts, the highest value of 66.7 g/l was found in rats treated with 6g/kg body weight while the lowest value of 64.3 g/l was in those treated with 3g/kg body weight
Summary
This reaearch aim was to evaluate some liver enzymes of albino rats subjected to administration of methanol and water extracts of Maytenus senegalensis and Cassia alata after infection with schistosome cercariae. The Total Bilirubin values of both methanol and water extracts for M. senegalensis (6.3-18.9μm/l) and (9.0-12.7μm/l) for C. alata and (4.2-6.3μm/l) for M. senegalensis and (4.1-6.4μm/l) for C. alata respectively were all within the normal values This indicates that all these extracts were well tolerated. This work is aimed at screening two medicinal plants as anti-schistosomal agents namely Cassia alata and Maytenus senegalensis and studying their effects on the biochemicals parameters of the host organism. To compare the properties of the various extracts of the plants using methanol and water as the extracting solvents
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