Effects of Matricaria chamomilla extract on motor coordination impairment induced by scopolamine in rats

Abstract

ObjectiveTo evaluate the effect of ethanolic extract of chamomile on balance and motor learning in rats receiving scopolamine and intact rats. MethodsFourty-two rats were divided into 6 groups (n = 7). Control group received distilled water. Rats in Group 2 were given 1 mg/kg scopolamine. Groups 3 and 4 received chamomile extract 200 mg/kg and 500 mg/kg, respectively, and scopolamine simultaneously for 20 days. Intact groups (Groups 5 and 6) only received chamomile extract 200 mg/kg and 500 mg/kg, respectively. Motor coordination of rats was assessed with rotarod apparatus. ResultsAccording to the obtained results, compared with the control group, scopolamine significantly decreased time spent on rotarod performance (P < 0.001). Compared with scopolamine group, the strength and staying on rotarod apparatus in Group 3 significantly increased (P < 0.05). The results of this research showed that intact groups that received only chamomile extract at doses of 200 mg/kg and 500 mg/kg significantly increased time spent on rotarod, compared with scopolamine group (P < 0.001). ConclusionsThe results of this study indicated the high antioxidant property and protective effect of chamomile extract on motor coordination in the groups that received scopolamine.