Abstract
TPS 742: Adverse birth outcomes 1, Exhibition Hall, Ground floor, August 27, 2019, 3:00 PM - 4:30 PM Neonicotinoid (NEO) is an environmental pollutant and few studies have been reported on biological monitoring and health effects. The study aims to explore the associations among NEO exposure, oxidative stress, and neonatal birth outcomes. A total 260 mother-infant pairs were selected in Taipei, Taiwan, during 2014-2016. Maternal urine samples were collected during the 3rd trimester of pregnancy, and the information of birth outcomes was retrieved from the medical records. We developed an isotope-dilution high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) method to simultaneously quantify seven neonics, including acetamiprid, clothianidin, dinotefuran, imidacloprid, thiacloprid, thiamethoxam and nitenpyram in urine. Urinary oxidative stress biomarkers (8-hydroxy-2’-deoxyguanosine (8-OHdG), 8-nitroguanine (8-NO2Gua)) and lipid peroxidation (8-iso-prostaglandin F2a (8-isoPF2a), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)) were analyzed by HPLC-MS/MS. All infants born to mothers with urinary 8-OHdG levels above the median exhibited a significantly shorter gestational duration. We anticipate this research will help to elucidate the mechanisms and the health effects by which NEO exposure affect and provide the finding to guide future policy for management and control of NEO.
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