Abstract
Marital status has long been recognized as an important prognostic factor for many cancers, however its’ prognostic effect for patients with laryngeal cancer has not been fully examined. We retrospectively analyzed 8834 laryngeal cancer patients in the Surveillance Epidemiology and End Results database from 2004 to 2010. Patients were divided into four groups: married, widowed, single, and divorced/separated. The difference in overall survival (OS) and cancer-specific survival (CSS) of the various marital subgroups were calculated using the Kaplan–Meier curve. Multivariate Cox regression analysis screened for independent prognostic factors. Propensity score matching (PSM) was also conducted to minimize selection bias. We included 8834 eligible patients (4817 married, 894 widowed, 1732 single and 1391 divorced/separated) with laryngeal cancer. The 5-year OS and CSS of married, widowed, single, and separated/divorced patients were examined. Univariate and multivariate analyses found marital status to be an independent predictor of survival. Subgroup survival analysis showed that the OS and CSS rates in widowed patients were always the lowest in the various American Joint Committee on Cancer stages, irrespective of sex. Widowed patients demonstrated worse OS and CSS in the 1:1 matched group analysis. Among patients with laryngeal cancer, widowed patients represented the highest-risk group, with the lowest OS and CSS.
Highlights
Marital status has long been recognized as an important prognostic factor for many cancers, its’ prognostic effect for patients with laryngeal cancer has not been fully examined
This study explored the effect of marital status on the survival rate of patients with laryngeal cancer by analyzing data from the Surveillance Epidemiology and End Results (SEER) database
The differences in demographic and pathological characteristics between the married group and the other three groups were statistically significant in terms of sex, age, race, grade, surgery, American Joint Committee on Cancer (AJCC) stage, radiotherapy, and chemotherapy (P < 0.001)
Summary
Marital status has long been recognized as an important prognostic factor for many cancers, its’ prognostic effect for patients with laryngeal cancer has not been fully examined. We included 8834 eligible patients (4817 married, 894 widowed, 1732 single and 1391 divorced/separated) with laryngeal cancer. The 5-year OS and CSS of married, widowed, single, and separated/divorced patients were examined. Subgroup survival analysis showed that the OS and CSS rates in widowed patients were always the lowest in the various American Joint Committee on Cancer stages, irrespective of sex. Among patients with laryngeal cancer, widowed patients represented the highest-risk group, with the lowest OS and CSS. Many studies have confirmed that marital status may affect the prognosis of various types of cancer, including endometrial c ancer[5], ovarian c ancer[6], glioblastoma m ultiforme7, chondrosarcoma[8] and male breast cancer[9]. This study explored the effect of marital status on the survival rate of patients with laryngeal cancer by analyzing data from the Surveillance Epidemiology and End Results (SEER) database
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