Abstract
The inhibitory effects of two different diuretic agents—mannitol and furosemide—on the rate of production of cerebrospinal fluid (CSF) were examined in cats by ventriculocisternal perfusion; each animal served as its own control. In 26 cats, mannitol effected as much as an 89% decrease in CSF formation as the serum osmolality was raised from 311 to 336 mosmol/liter by intravenous mannitol infused at rates from 2 to 10 mg/kg/min. The degree of decrease was a linear function of the rise in serum osmolality. Furosemide was shown to reduce CSF production by as much as 94% when intravenous doses of 0.87 to 20.3 mg/kg were used in 25 animals. The decrease was dependent on the natural logarithm of the dose. Intraventricular furosemide at concentrations of 0.06 to 0.24 mg/ml was very effective in 10 cats, without causing saluresis or diuresis. This effect was also linearly related to the natural logarithm of the concentration.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
