Abstract
The research work was aimed at investigating physiological, biochemical, analgesic and anesthetic indices of dogs anesthetized with propofol-ketamine and maintained with repeat bolus and constant infusions of propofol. Eight dogs, assigned to two groups (n=4), were used in this study. All dogs were pre-medicated with atropine (at 0.03 mg/kg bwt) and xylazine (at 2 mg/kg bwt). Anesthesia was induced by a concurrent administration of propofol (at 4 mg/kg bwt) and ketamine (at 2.5 mg/kg bwt). Maintenance of anesthesia in Group 1 was done with a repeat bolus of propofol (at 2 mg/kg bwt), while in Group 2 it was done with a constant infusion of propofol (at 0.2 mg/kg bwt/min). Gastrotomy was performed in both groups, and anesthesia was maintained for 60 min. Physiological, analgesic, anesthetic parameters and plasma glucose concentration were measured. There was no significant (P>0.05) difference found in the analgesia and pedal reflex scores, durations of analgesia and recumbency, recovery time and standing time between the groups. The heart rate, respiratory rate and rectal temperature reduced significantly (P
Highlights
Propofol, 2, 6-diisopropyl phenol, is an anesthetic agent belonging to the alkyl phenol group (Hall et al, 2001)
The limitation of using propofol associated with the short duration of action has been largely addressed with the introduction of the repeat bolus and the constant infusion of propofol as maintenance protocols for anesthesia
The mean analgesia score was greater than 4.5 in both groups (Figure 1), and the score did not differ significantly (P>0.05) between the groups. This similarity in the analgesia score was observed in the mean pedal reflex score, where the score in both groups reduced over time throughout the procedure
Summary
2, 6-diisopropyl phenol, is an anesthetic agent belonging to the alkyl phenol group (Hall et al, 2001). The use of the repeat bolus technique is an older technique which has been largely replaced by the constant infusion of propofol, as revealed by the trend in recent researches (Seliskar et al, 2007; Wiese et al, 2010; Chui et al, 2014; Dahi et al, 2015). The reason for this shift has not been sufficiently documented
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