Abstract
Following oral injections of either 0, 5, or 20 mg/kg of magnesium pemoline mixed with tragacanth in an equal volume solution, 60 Long-Evans hooded rats were given 70 trials in a two-compartment one-way avoidance apparatus. Type of CS (light vs buzzer) and interval between drug injection and conditioning (30 vs 60 min) were varied factorially with drug dosage. Ss receiving either 5 or 20 mg/kg of magnesium pemoline performed significantly better than did controls, independent of the other two variables. These results fail to support the Beach & Kimble (1967) hypothesis that the major effects of magnesium pemoline on avoidance conditioning are due to an increased aversive responsiveness to a buzzer CS, which has typically been employed in studies of the drug, rather than directly affecting the avoidance learning.
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