Abstract
The present study investigated possible benefits of magnesium ion (as MgCl2) in organophosphorus poisoning targeting its ability to interact with substrates and membrane enzymes. Blood samples collected from volunteered healthy adult by venepuncture into anticoagulant test tubes containing EDTA were separated into plasma and red blood cell and divided into three groups namely: normal, pesticide only (0.25‐2.0 mmol/L chlorpyrifos) and pesticide (0.25‐2.0 mmol/L chlorpyrifos) + 0.1 mol/L MgCl2. Acetylcholinesterase, Na+/K+ ATPase and Ca2+ ATPase activities were evaluated. Results showed that Chlorpyrifos significantly (P < .05) reduced the levels of cholinesterase both in plasma and on red blood cells. Red blood cells Na+/K+ ATPase and Ca2+ ATPase were also significantly (P < .05) reduced by chlorpyrifos while MgCl2 counteracted effects of chlorpyrifos with significant (P < .05) increase in the levels of cholinesterase, Na+/K+ ATPase and Ca2+ ATPase. We concluded that MgCl2 neutralized effects of chlorpyrifos by promoting normal ATPase activities and inhibiting release of acetylcholine from cell.
Highlights
Pesticides are substances that are used to prevent, destroy, repel, and mitigate a host of unwanted organisms called pests.[1]
The aim of the present study was to investigate in vitro the possible benefits of magnesium ion in organophosphorus poisoning targeting its ability to interact with substrates and membrane enzymes
The present study investigated benefits of magnesium ion in organophosphorus poisoning targeting its ability to interact with substrates and membrane enzymes
Summary
Pesticides are substances that are used to prevent, destroy, repel, and mitigate a host of unwanted organisms called pests.[1] Pesticides are mostly not selective and their exposure are toxic to many nontargets including humans. Organophosphorus pesticide poisoning has being a serious public health concern in developing countries.[2] In northern part of Nigeria where farming is their major occupation, chlorpyriphos is Abbreviation: ATP, Adenosine triphosphate; Ca2+ ATPase, Calcium adenosine triphosphate; ChE, Cholinesterase; EDTA, Ethylenediaminetetraacetic acid; KCl, Potasium chloride; MgCl2, Magnesium chloride; MgSO4, Magnesium sulphate; NaCl, Sodium chloride; Na+/K+ ATPase, Sodium/potasiun adenosine triphosphate; TCA, Trichloroacetic acid; TrisHCl, Tris-hydrochloride. About one million unintentional and two million self poisonings with pesticides occur worldwide, and of these, approximately 200 000 die.[5]
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