Abstract
The effects of Mg 2+ and Ca 2+ ions on the activities of mitochondrial and cytosolic aldehyde dehydrogenases isolated from horse, rat, and beef livers were investigated in 0.1 M sodium phosphate, pH 7.5, at 25°C. As with the Mg 2+-enhancement of the horse liver mitochondrial enzyme [17], Mg 2+-activation was observed for the mitochondrial enzymes from rat and beef. The cytosolic enzymes from horse, rat, and beef livers were inhibited in the presence of Mg 2+ ions. The effects of Ca 2+ ions on the activity were essentially the same as those observed in the presence of Mg 2+ ions; the mitochondrial isozymes were activated while the cytosolic isozymes were inhibited. The fact that only the activity of mitochondrial forms of mammalian liver aldehyde dehydrogenase was enhancd by Ca 2+ or Mg 2+ ions may be related to the in vivo regulation of aldehyde metabolism, a presumed mitochondrial event.
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