Abstract
On a single conditioning trial, a 1-sec electric shock (.125 or.250 mA) was administered when rats entered a darkened chamber from a lighted elevated runway. Latency to enter the chamber was recorded on retention trials given 24 and 48 h later. Animals received subcutaneous injections of varying doses of lysine vasopressin or a placebo solution immediately after the training trial or immediately before the first retention trial. Nonshocked control animals showed no increase in response latencies on successive trials, nor was there a difference between the placebo and vasopressin groups under the “no-shock” condition. Treatment with lysine vasopressin increased resistance to extinction, irrespective of the time of treatment.
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