Abstract
<p class="Abstract"><em>Alchemilla mollis</em>, is used in traditional medicine for the treatment of wounds and excessive menstruation. Aqueous methanol extracts of<em> A. mollis</em> and <em>A. persica</em> were evaluated for wound healing acivity by using linear incision and circular excision wound models along with hydroxyproline estimation and histopathological analysis. Anti-inflammatory effect was determined according to Whittle method. The extracts prepared from the aerial parts of <em>A. mollis</em> and <em>A. persica</em> exerted significant wound healing activity with the tensile strength values of 39.3% and 33.3%, respectively, and with the contraction values of 51.4% and 43.5%, respectively. Hydroxyproline estimation and histopathological analysis also confirmed the results. The extracts of <em>A. mollis</em> and <em>A. persica</em> showed significant anti-inflammatory activity with the values of 30.6% and 26.6% respectively. These results showed that <em>A. mollis</em> and <em>A. persica</em> possess significant wound healing and anti-inflammatory activities.</p><p class="Abstract"><strong>Video Clip</strong></p><p class="Subheading"><a href="https://youtube.com/v/k2Hz7f1e4SI">Circular excision wound model</a>: 2 min</p><p> </p>
Highlights
Alchemilla genus plants are herbaceous perennial plants from the family Rosaceae, known as their common name “Lady’s mantle”
Voucher specimen of A. mollis was deposited in Herbarium of Cumhuriyet University, Faculty of Science (CUFH 1344) and the voucher specimen of A. persica was kept in the Herbarium of Ankara University, Faculty of Pharmacy (AEF 25896)
The extracts prepared from the aerial parts of A. mollis and A. persica exerted significant wound healing activity with the tensile strength values of 39.3% and 33.3%, respectively on the incision wound model, and with the contraction values of 51.4% and 43.5%, respectively on the excision wound model (Table I, II)
Summary
Alchemilla genus plants are herbaceous perennial plants from the family Rosaceae, known as their common name “Lady’s mantle”. In traditional medicine, Alchemilla species have been used internally for the treatment of menopausal complaints, dysmenorrhea, gastrointestinal disorders, mouth and throat inflammation and externally for ulcers, eczema and skin rashes (Kupeli Akkol et al, 2015). One of these species, A. mollis, is used in traditional medicine for the treatment of wounds and excessive menstruation (Makau et al, 2013; Trendafilova et al, 2011; Yarnel and Abascal, 2009). This study was designed to screen the wound healing activity potential of two Alchemilla species namely, A. mollis and A. persica, growing wild in Turkey, by conducting in vivo bioassays
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