Abstract
SUMMARY The effects of long wave ultraviolet radiation (320–400 nm) on the binding of twenty-five fluorescent photosensitizing and related compounds to the major saline soluble guinea-pig epidermal proteins were studied. Binding before or after irradiation was detected on polyacrylamide disc gel electrophoresis by correlating the fluorescent migration pattern with the amido black counterstained pattern. Effects were seen only on photo-allergic and structurally related compounds (phenothiazines and halogenated salicylanilides). The binding of five phenothiazine derivatives was detected only after irradiation. Ten of twelve halogenated salicylanilides were bound without irradiation, and eleven were bound following it. Ultraviolet exposure appeared to increase the amount of each halogenated salicylanilide that was bound and/or to alter the existing complex.
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