Abstract
The infusion of 0.75 mg/kg/h sodium nitroprusside (SNP) for 40 h in rabbits leads to a significant rise of the plasma thiocyanate concentration, irrespective of whether SNP was infused alone or in combination with sodium thiosulphate (ST). The iron concentration in the plasma is slightly increased, but the iron-binding capacity is not exceeded. The infusion of SNP in rabbits resulted in an elevation of the non-Hb iron in the liver in every case. About 60% of the infused SNP iron is found in the liver, whilst after FeSO4 infusion only about 30% of the administered iron is deposited in the liver. The higher iron content of the liver after SNP-infusion shows that SNP-iron is not taken up in free ionic form in this organ. The question of whether and to what extent the complex is broken down before being taken up remains unanswered.
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