Abstract
The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW intake and HI remains elusive. In the present study, the body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI. Among the 13 parameters, the most striking alterations induced by hydrogen treatment were observed in serum myocardial enzymes spectrum. The results also showed that the changes in these parameters occurred at different time points, and the alterations in most of the parameters were much more significant in HI than HRW. The results of this study provides the basic data for the mechanism research and application of molecular hydrogen in the future.
Highlights
The potential therapeutic effects of molecular hydrogen (H2) have been confirmed in various human and animal-disease models
The results showed that after two weeks of hydrogen inhalation (HI), the body weight (BW) of the rats was markedly lower than the controls (315.10 ± 4.81 g vs. 335.60 ± 4.72 g, p = 0.0043) (Fig. 1B)
Until January 2020, more than 1300 scientific publications regarding the biological effects of molecular hydrogen have been published, accumulating evidence from preclinical or clinical studies indicated the therapeutic potential of H 2 on the progression of organ damage in various types of disease models
Summary
The potential therapeutic effects of molecular hydrogen (H2) have been confirmed in various human and animal-disease models. The body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI. The potential therapeutic effects of H2 have been confirmed in over 170 different human and animal-disease models[4], the effects of hydrogen therapy, especially long term hydrogen intervention, on the physiological function in a normal state remains largely unknown. Oral intake of HRW and inhalation of hydrogen gas are the most common routes of hydrogen therapy in clinical trials, there is a lack of detailed comparative study on the effects of these two hydrogen delivering methods at present. The purpose of the present study was to determine the effects of long term of oral intake of HRW and inhalation of hydrogen gas on the physiological function of healthy rats. The results of this study could provide basic data for further research on hydrogen medicine
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