Effects of long-term cadmium exposure on the testis of rabbits: Ultrastructural study

Abstract

Six male rabbits received for 9 months drinking water containing 20 μg/ml of cadmium (Cd). At the end of the treatment, the Cd contents of kidney and testis were 175 ± 34 and 0.8 ± 0.2 μg/g wet weight, respectively. Ultrastructural examination by transmission electron microscopy (EM) showed that, in the Sertoli cells, the size of the lysosomes was increased; spermatogenetic cells, vessels and Leydig cells showed no significant alterations. Observations with both transmission and scanning EM did not evidence changes in the blood-testis barrier, but our results do not exclude that male fertility may be affected by chronic exposure to cadmium.