Abstract
Urothelial cell carcinoma (UCC) is one of the major malignancies of the genitourinary tract, and it is induced by carcinogenic epidemiological risk factors. H19 is one of the most crucial long noncoding RNAs (lncRNAs) and is involved in various types of bladder cancer. In this study, we examined H19 single-nucleotide polymorphisms (SNPs) to investigate UCC susceptibility and clinicopathological characteristics. Using real-time polymerase chain reaction, we analyzed five SNPs of H19 in 431 UCC patients and 431 controls without cancer. The results showed that patients with UCC carrying the H19 rs217727 CT + TT and rs2107425 CT + TT genetic variants had a high risk of developing muscle invasive tumors (pT2–T4) (p = 0.030; p = 0.025, respectively). With a median follow up of 39 months, CT+TT polymorphisms of rs2107425 were associated with worse disease-specific survival (adjusted hard ratio (AHR) = 2.043, 95% confidence interval (CI) = 1.029-4.059) in UCC patients aged older than 65 years. In conclusion, our results indicate that patients with UCC carrying the H19 rs217727 CT + TT and rs2107425 CT + TT genetic variants have a high risk of developing muscle invasive tumors. Thus, H19 polymorphisms may be applied as a marker or therapeutic target in UCC treatment.
Highlights
Bladder cancer is the fourth most common cancer in men and the eleventh most common cancer in women worldwide [1]
Epidemiology and risk factors such as smoking, occupational exposure to polycyclic aromatic hydrocarbons, aromatic amines, and heavy metals, and genetic predisposition have been suggested to be associated with urothelial bladder cancer (UBC) [4,5]
We revealed the association of H19 single-nucleotide polymorphisms (SNPs) with Urothelial cell carcinoma (UCC) susceptibility and clinical status
Summary
Bladder cancer is the fourth most common cancer in men and the eleventh most common cancer in women worldwide [1]. 90% of all bladder cancers are urothelial cell carcinomas (UCCs) [2]. In Taiwan, UCC ranks twelfth and thirteenth for mortality rates among all cancer deaths in male and female patients with bladder cancer [2,3]. Epidemiology and risk factors such as smoking, occupational exposure to polycyclic aromatic hydrocarbons, aromatic amines, and heavy metals (such as cadmium, chromium, nickel, lead), and genetic predisposition have been suggested to be associated with urothelial bladder cancer (UBC) [4,5]. Accumulating evidence suggests that long noncoding RNAs. Int. Res. Public Health 2019, 16, 1322; doi:10.3390/ijerph16081322 www.mdpi.com/journal/ijerph
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