Abstract
Objectives: The goal of this research was to evaluate the effects of Platelet Rich Fibrin (PRF) in reducing post-surgical complications as pain, swelling, and trismus after surgical extraction of impacted lower third molars. Methods: A total of 44 patients who fulfilled the inclusion criteria were chosen to take part in this research. Postoperative pain was assessed using a numerical rating scale (NRS). Facial swelling was measured by a modification of tape measure method. To assess trismus, the maximal interincisal mouth opening was measured by using a digital caliper scale (electronic vernier). Results: In the Platelet Rich Fibrin PRF group; the results showed a significant difference of levels of pain experienced (NRS) in the 1st postoperative day in comparison to the control group. In regard to post-operative swelling; a significant decrease in the 3rd postoperative day was observed in comparison to the control group. With regard to trismus; no significant differences between groups regarding interincisal mouth opening was noticed. Conclusions: The application of PRF reduces the severity of the immediate postoperative sequelaes.
Highlights
The main complications that may follow the removal of mandibular third molars by surgery are inflammation, delayed wound healing, facial swelling, pain, and trismus
Patients were recalled on the postoperative 1st, 3rd, and 7th days after surgical extraction of impacted mandibular third molar to evaluate pain, facial swelling, and trismus
Platelet rich fibrin (PRF) acts as a scaffold that is able to guide epithelial cell migration and in carrying cells involved in tissue regeneration (17,18)
Summary
The main complications that may follow the removal of mandibular third molars by surgery are inflammation, delayed wound healing, facial swelling, pain, and trismus. Studies have demonstrated the beneficial effect of the use of nonsteroidal and steroidal anti-inflammatory drugs following surgery in minimizing odema and trismus(2,3). These drugs may result in significant systemic side effects and are contraindicated in some patients due to their potential side effects such as delayed wound healing, adrenal suppression, and increased susceptibility to infection(4,5). Several studies have shown that PRF has facilitated the healing of wounds such as following the removal of cysts, sinus augmentations and periodontal defects (6, 9, 10) The goal of this clinical trial was to investigate whether there is any beneficial value of local application of platelet rich fibrin clot on the postoperative swelling, pain, and trismus
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