Effects of loading rate, age, and morphology on the material properties of human rib trabecular bone

Abstract

The material and morphometric properties of trabecular bone have been studied extensively in bones bearing significant weight, such as the appendicular long bones and spine. Less attention has been devoted to the ribs, where quantification of material properties is vital to understanding thoracic injury. The objective of this study was to quantify the compressive material properties of human rib trabecular bone and assess the effects of loading rate, age, and morphology on the material properties. Material properties were quantified via uniaxial compression tests performed on trabecular bone samples at two loading rates: 0.005 s−1 and 0.5 s−1. Morphometric parameters of each sample were quantified before testing using micro-computed tomography. Rib trabecular bone material properties were lower on average compared to trabecular bone from other anatomical locations. Morphometric parameters indicated an anisotropic structure with low connectivity and a sparser density of trabeculae in the rib compared to other locations. No significant differences in material properties were observed between the tested loading rates. Material properties were only significantly correlated with age at the 0.005 s−1 loading rate, and no morphometric parameter was significantly correlated with age. Trabecular separation and thickness were most strongly correlated with the material properties, indicating the sparser trabecular matrix likely contributed to the lower material property values compared to other sites. The novel trabecular bone material properties reported in this study can be used to improve the thoracic response and injury prediction of computational models.