Abstract
• LCP or the combination of LCP and sodium selenite alleviated osteoporosis of mice through Wnt/β-catenin pathway. • LCP or the combination of LCP and sodium selenite alleviated osteoporosis of mice through OPG/RANKL/NF-kB pathway. • LCP or the combination of LCP and sodium selenite increase bone biomechanical properties of mice. The effects of loach skin collagen peptides (LCP) and the combination of LCP and sodium selenite on osteoporosis in mice were investigated. The results showed that the combination of LCP and sodium selenite alleviated mice osteoporosis induced by retinoic acid. It improved bone microarchitecture, increased the number and mass of trabecular bone, maintained blood calcium and phosphate balance in mice. The combination of LCP and sodium selenite inhibited the relative mRNA expression levels of Wnt10, β-catenin, osteogenic transcription factors Runx2 and Osterix through the Wnt/β-catenin pathway. The ratio of receptor activator for nuclear factor-kB ligand/Osteoprotegerin (RANKL/OPG) was down-regulated through the OPG/RANKL/NF-kB pathway. Likewise, the relative mRNA expression levels of tumor necrosis factor receptor associated factor 6 (TRAF6), nuclear factor kB (NF-kB) and nuclear factor of activated T-cell (NFATC1) were reduced. This study provides useful information for the use of LCP and sodium selenite in treating and reduction of osteoporosis.
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