Effects of liposome prostaglandin E1 on prethrombotic state of patients with severe burn

Abstract

Objective To observe the effects of liposome prostaglandin E1(Lipo-PGE1) on prethrombotic state of patients with severe burn. Methods Twenty-five patients with severe burn whose total burn area≥ 50% total body surface area(TBSA) and/or burn area of degree Ⅲ≥ 20% TBSA were randomly divided into Lipo-PGE1 group(n=15) and control group(n=10).Patients in both groups were given conventional treatment after admission,and those in Lipo-PGE1 group were managed with intravenous injection of Lipo-PGE1(10 μg once a day for 7 d).Blood samples were collected 1 d,2 d,3 d,7 d and 14 d after burn,and antithrombin antigen(AT:Ag),antithrombin activity(AT:A),protein C activity(PC:A),protein S activity(PS:A),P-selectin(P-sel),soluble fibrin monomer complex(SFMC) and plasmin-α2-antiplasmin complex(PAP) were determined.Thromboelastogram(TEG) was recorded with coagulation analyzer,and the parameters of TEG in Lipo-PGE1 group were compared before and after treatment to assess the coagulation function.Results There was no significant difference in AT:Ag,AT:A,PC:A,PS:A,SFMC and PAP between tow groups at different time points after burn(P0.05).The expression of P-sel in Lipo-PGE1 group was significantly lower than that in control group 3 d and 7 d after burn(P0.05).Analysis of TEG parameters revealed that the thromboplastin generation time was(3.77±0.90) min before treatment and(4.98±0.72) min after treatment in Lipo-PGE1 group,and the latter was significantly longer than the former(P0.05). Conclusion Early application of Lipo-PGE1 after severe burn may effectively improve the prethrombotic state.