Abstract
In this study, lipopolysaccharides (LPS) of Pseudomonas aeruginosa IAN5 isolate and aqueous extract of Ginkgo biloba leaves were used to investigate the cellular immunity in mice Balb/c (in vivo). Some parameters were used to achieve this study, are percentages of polymorphonuclear neutrophils (PMNs), phagocytosis coefficient of PMNs at different time periods 30, 60, 90 and 120 minutes, Formazan granules formation in them, and migration inhibition factor (MIF). The immunization of mice with the LPS antigen affected delay-type hypersensitivity and increased activity of PMNs in Candida sp. and reduced NBT, while inhibited migration of PMNs. The immunization did not affect the macrophages of PMNs. The injected treatment with LPS and Ginkgo biloba extract showed the best results significantly (p<0.05) compared to LPS and control treatments, whereas the Ginkgo biloba extract alone showed no significant differences (p<0.05).
Highlights
Bu çalışmada, Pseudomonas aeruginosa IAN5 izolatının lipopolisakkaridleri (LPS) ve Ginkgo biloba yapraklarının sulu özütü, Balb/c farelerde hücresel bağışıklığı araştırmak için kullanıldı
Tang et al (2017) referred that murine acid-rich LPS induces monocytes to produce a high level of INF and IL-1 which increase the adherence of basophils with endothelium vessels inhibition their migration to the infection place
Lipopolysaccharides induce macrophages and monocytes to secrete TNF-α, IL-6, and IL-1 through their linking with Lipopolysaccharide Binding Protein to form Lipopolysaccharide Binding Protein Complex which links with the receptors CD14 or TLR-4 (5)
Summary
Pseudomonas aeruginosa IAN5 izolatının lipopolisakkaridleri (LPS) ve Ginkgo biloba yapraklarının sulu özütü, Balb/c farelerde (in vivo) hücresel bağışıklığı araştırmak için kullanıldı. This work investigates the induction of the response of cellular immunity in vivo by Ginkgo biloba extract and Lipopolysaccharides of Pseudomonas aeruginosa IAN5 (local isolate). Effect of the immunization by using lipopolysaccharides (LPS) of Pseudomonas aeruginosa and extract of Ginkgo (Ginkgo biloba) on the survival of basophile is reported in table 1.
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