Abstract
Objective To investigate the effects of lipitor combined with probucol on prevention of contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with coronary heart disease and its influence on renal function, inflammatory factors and oxidative stress. Methods A total of 150 patients with coronary heart disease undergoing PCI in Quanzhou First Hospital from June 2016 to June 2017 were selected for study and were divided into the combined group and the control group according to the random number table method, with 75 cases in each group. The control group was given oral lipitor before operation, and the combined group was given the probucol on this basis. The levels of the renal function indexes including serum creatinine (Scr), cystatin-C (Cys-C), neutrophil gelatinase-associated lipocalin (NGAL), inflammatory factors, such as serum high-sensitivity-C reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-18 (IL-18), and oxidative stress indexes including 8- isoprostaglandin -F2α (8-iso-PGF2α), 8-hydroxy-2’-deoxyguanosine (8-OHdG), malondialdehyde (MDA) before operation and 48 h after operation were compared between the two groups. The occurrence of adverse drug reactions and the CIN morbidity in the two groups within 3 d after operation were analyzed. Results There was no significant difference in the levels of serum Scr, Cys-C or NGAL in the combined group 48 h after operation compared with those before operation (P all>0.05), but the levels were significantly lower than those in the control group at the same time (P all 0.05), and the CIN morbidity in the combined group was significantly lower than that in the control group (P<0.05). Conclusions Lipitor combined with probucol can significantly control the levels of inflammatory factors and oxidative stress and maintain their renal function in patients with coronary heart disease, and then effectively prevent CIN, and it is favorable for the postoperative recovery of patients. Key words: Lipitor; Probucol; Percutaneous coronary intervention; Contrast-induced nephropathy
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