Abstract
ABSTRACTBackground and Objective:Maternal under nutrition and low birth weight babies are among the common tragedies of developing countries like Pakistan. Preeclampsia and its significant association with fetal growth restriction due to spiral arteries remodeling and trophoblastic invasion decreases nutritional supply to growing fetus added by maternal under nutrition. This study was designed to see the effects of lipid based nutritional supplements for pregnant and lactating women LNS-PLW on maternal and fetal outcome of pre-eclampsia.Methods:Sixty underweight pre-eclamptic women were randomly assigned into two study Groups from April 2018 to December 2019 at the antenatal units of the tertiary Health care facilities of Lady Reading Hospital, Hayatabad Medical Complex Peshawar and Civil Hospital Matta Swat, KPK Pakistan in a randomized clinical trial. Participants were on routine drugs for pre-eclampsia and Iron and Folic Acid (60mg, 400 μg) daily, while participant of Group-2 (n=30) received one sachet of Lipid based nutritional supplement for pregnant and lactating women LNS-PLW in addition daily till delivery. The birth weight, gestational age, head-circumference, and birth length of babies were measured.Results:The significant improvement found in the birth weight (p-value 0.003), gestational age (p-value 0.006), head circumference (P-value of 0.0006) and birth length (P-value of 0.0017) of babies of Group-2 women. We observed that addition of Lipid based nutritional supplement for pregnant and lactating women LNS-LPW improved the birth outcome in underweight women of pre-eclampsia.Conclusion:The Prenatal supplementation of Lipid based nutritional supplement for pregnant and lactating women LNS-PLW can improve birth weight, gestational age, length and head circumference of babies of underweight preeclamptic women.
Highlights
Preeclampsia is a multisystem disorder originating from placenta
The base line obstetrics and clinical characteristics were similar in both Groups i.e. Iron and Folic acid Group-1 and lipid based nutritional supplement for pregnant and lactating women Group-2
Pregnancy and fetal outcomes: The birth outcomes of study are summarized in Table-IV
Summary
Preeclampsia is a multisystem disorder (proteinuria, hypertension and edema after 20 weeks of gestation) originating from placenta. Pak J Med Sci January - February 2022 Vol 38 No 1 www.pjms.org.pk 219 hypertension diseases, including preeclampsia, have been shown to occur more frequently in first pregnancies and less frequently in subsequent pregnancies.[2]. It is responsible for several short and long term maternal and neonatal complications. This study was designed to see the effects of lipid based nutritional supplements for pregnant and lactating women LNS-PLW on maternal and fetal outcome of pre-eclampsia. Conclusion: The Prenatal supplementation of Lipid based nutritional supplement for pregnant and lactating women LNS-PLW can improve birth weight, gestational age, length and head circumference of babies of underweight preeclamptic women
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