Abstract
Overweight and obesity are highly prevalent in developed countries and are also becoming more frequent in the developing world. Overweight and obese patients have elevated levels of several inflammatory markers and this inflammatory state might contribute to their increased vascular risk. We summarize the effects of lifestyle changes, antiobesity agents, and bariatric surgery on serological inflammatory markers in overweight and obese patients. Most studies showed a decrease in inflammation with all 3 interventions. However, it remains to be established whether the decrease in inflammatory markers induced by lifestyle changes or (where indicated) with antiobesity agents or bariatric surgery will translate into reduced vascular morbidity and mortality in overweight and obese patients.
Highlights
Overweight and obesity are highly prevalent in developed countries [1]
We summarize the effects of lifestyle changes, antiobesity agents, and bariatric surgery on serological inflammatory markers in obese patients
Existing evidence suggests that lifestyle measures, antiobesity agents, and bariatric surgery reduce serum levels of inflammatory markers in obese patients
Summary
Overweight and obesity are highly prevalent in developed countries [1]. The activation of inflammation that is present in obesity might contribute to the increased vascular morbidity and mortality of these patients, since elevated levels of inflammatory markers are associated with increased vascular risk [42,43,44,45,46]. We summarize the effects of lifestyle changes, antiobesity agents, and bariatric surgery on serological inflammatory markers in obese patients
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