Effects of lidocaine on cisatracurium neuromuscular conduction in neurosurgery

Abstract

Objective To investigate the effects of lidocaine on cisatracurium neuromuscular conduction in neurosurgery. Methods Sixty patients with ASA Ⅰ-Ⅱ grade who were going to undergo neurologist surgery under general anesthesia were randomly allocated to group L (lidocaine group) and group S (control group). Group L was injected with 1.5 mg/kg lidocaine intravenously in induction phase, and then was injected with it continuously at speed of 3 mg/(kg·h) till the suturing; group S received sodium chloride injection of same dosage. Muscle relaxant onset time (when TOF=0 after cisatracurium infusion), muscle relaxant recovery time (from TOF=3 to 25% of TOF recovered), muscle relaxant maintenance time (from TOF=3 to 50% of TOF recovered) of the two groups were recorded and compared; intraoperative mean dosage of cisatracurium and changes of hemedynamics of the two groups were recorded and compared. Results There was no significant difference in muscle relaxant onset time between group L and group S (P>0.05), and were significant differences in muscle relaxant recovery time and muscle relaxant maintenance time between the two groups (both P<0.05). Compared with group L, the average consumption of cisatracurium was lower in group S (P<0.05). Conclusions Lidocaine does not effect cisatracurium neuromuscular block onset time, but can prolong the duration of the muscle relaxant effect. Key words: Lidocaine; Cisatracurium; Neuromuscular conduction; Neurosurgery; General anesthes