Abstract
Leukotriene C 4 (LTC 4) enhanced the association of mouse peritoneal macrophages (MPM) with Trypanosoma cruzi, increasing the proportion of MPM associating with parasites and the number of trypanosomes per MPM. LTC 4 affected both cells since pretreatment of either one increased the association. LTC 4 also enhanced MPM uptake of killed T. cruzi or latex beads, denoting stimulation of phagocytosis. However, since LTC 4 pretreatment of rat heart myoblasts - nonphagocytic cells - also increased the association, host cell membrane alterations induced by LTC 4 may also facilitate parasite invasion. Inhibition of MPM guanylate cyclase abrogated the LTC 4 effect, suggesting a role for elevated levels of cyclic GMP. LTC 4 also increased the rate of intracellular parasite killing by MPM. These results suggest that LTC 4, occurring in inflammation such as develops in T. cruzi infection, regulates parasite clearance by MPM by increasing uptake and intracellular destruction.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
