Abstract
Effects of leech salivary extract (lse) on indices of liver function in rats
Highlights
Biochemical analyses are useful in chronic toxicity studies because they serve as indicators of cell damage when enzymes are leaked into the blood as a result of exposure of the cell to certain chemical compounds [1]
Significant (p0.05) elevation in Aspartate transaminase (AST) was recorded in the 100 mg/kgbw leech salivary extract (LSE) group compared with the Control
The LSE as well as dexamethasone (3) and jobelyn (4.17) insignificantly (p0.05) reduced the alanine transaminase (ALT) level when compared with control
Summary
Biochemical analyses are useful in chronic toxicity studies because they serve as indicators of cell damage when enzymes are leaked into the blood as a result of exposure of the cell to certain chemical compounds [1]. Alanine transaminase (ALT) is another parameter used to assess liver ill health It is a marker enzyme formally known as serum glutamate-pyruvate transaminase (SGPT). ALP is a marker enzyme of the plasma membrane and endoplasmic reticulum, a by-product of osteoblast activity and an enzyme present in the cells lining the bile duct of the gall bladder in the liver [3]. It functions in splitting cholesterol and long chain fatty acids [4]. Proteins are important building blocks of all cells needed for the body’s growth, development and health
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