Effects of Lead Exposure on Growth and Bone Biology in Growing Rats Exposed to Simulated High Altitude

Abstract

The existence of children living at high altitude suffering from lead (Pb) poisoning prompted us to investigate the long term effects of this pollutant on growth and bone biology in growing rats maintained at simulated high altitude (SHA). Pb and hypoxia (HX) significantly reduced body weight (-9.4 % and -24 %; p < 0.01) and length (-3 % and -8 %; p < 0.01); decreased femoral ultimate load (-16 % and -40 %; p < 0.01) and femoral energy absorption capacity (-18 % and -74 %; p < 0.01). Oral pathologic alterations were observed in experimental groups. Our findings revealed growth retardation and damages on femoral and mandibular bones that predispose to fractures.