Abstract
Background: A major problem of aging is the disruption of metabolic homeostasis. This is particularly relevant in the brain where it provokes neurodegeneration. Caloric restriction is a physiologic intervention known to delay the deleterious consequences of aging in several species ranging from yeast to mammals. To date, most studies on experimental models have started this dietary intervention from weaning, which is very difficult to be translated to human beings. Here, we study the effects of a more realistic dietary regimen in rats, starting at an advanced age and lasting for six months. Methods: we analyzed in the cortex and hippocampus, the proteins involved in the energetic balance of the cells, cholesterol metabolism, oxidative stress response, inflammation, synaptic impairment, and brain trophism. Results: our results suggest that caloric restriction in late life can revert only some age-related changes studied here.
Highlights
Aging entails a progressive decline in physiological functions of the body and increases the probability of getting sick and of dying [1]
Methods: we analyzed in the cortex and hippocampus, the proteins involved in the energetic balance of the cells, cholesterol metabolism, oxidative stress response, inflammation, synaptic impairment, and brain trophism
We focused on proteins involved in key processes modulated by aging, namely the energetic status of the cells, cholesterol metabolism, oxidative stress response, inflammation, synaptic impairment, and brain trophism
Summary
Aging entails a progressive decline in physiological functions of the body and increases the probability of getting sick and of dying [1]. Cells in the brain are sensitive to aging. As an example, aging decreases the energy status of cells [4] and disrupts lipid homeostasis, namely cholesterol metabolism [5]. Other alterations in the brain include increased oxidative stress [6] and inflammation [7], synaptic impairment [8], and decreased brain trophism [9]. A major problem of aging is the disruption of metabolic homeostasis. This is relevant in the brain where it provokes neurodegeneration. Methods: we analyzed in the cortex and hippocampus, the proteins involved in the energetic balance of the cells, cholesterol metabolism, oxidative stress response, inflammation, synaptic impairment, and brain trophism. Results: our results suggest that caloric restriction in late life can revert only some age-related changes studied here
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