Abstract
Twelve Holstein bull calves were ruminally cannulated at 5 d of age and assigned to 0 or 1mg of lasalocid/kg of BW daily, administered postruminally via milk replacer or into the ruminal cannula. Calves were fed milk replacer for 8 wk and calf starter for 12 wk. Lasalocid administration was terminated at weaning in calves fed lasalocid in milk replacer. Ruminal pH tended to be higher in calves fed lasalocid ruminally than in calves on control treatment and averaged 5.9 and 5.6 and 5.4 and 5.1 during wk 1 to 8 and 9 to 12, respectively. Molar proportion of ruminal butyrate tended to be lower when lasalocid was added to the rumen, particularly after weaning. Blood β-hydroxybutyrate and acetoacetate were lower when lasalocid was administered into the rumen after weaning and averaged .897 and .646 and .026 and .015mM in calves on control and ruminal treatments, respectively. No effects of lasalocid administered via the milk replacer were observed, except for plasma NEFA, which were reduced postweaning. These data suggest that lasalocid reduces blood β-hydroxybutyrate by changes in ruminal fermentation and subsequent metabolism of butyrate by ruminal epithelium.
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