Abstract

Background: Effects of Lactobacillus acidophilus on some physiological and morphological aspects of intestinal mucosa in adult male rats with experimentally induced colitis were studied. Material & methods: Thirty six male rats were divided into equal four groups , 9 of each . The 1 st control one( C) while the others were designated as T1,T2,T3, rats of C and T3 group received 1ml of D.W, while those of T1&T2 received Lactobacillus acidophilus at a dose of (5×108 CFU ) for two weeks ,as a pre colitis period, then acetic acid colitis induced for rats of T2 & T3and sham colitis for rats of C &T1, seven days later , at the end of post colitis period, D-xylose absorbance test, food intake, body weight, and FCR ratio were studied in addition to intestinal morphological changes. Results: revealed that L. acidophilus administration to AA colitis rats was useful in increase significantly (p<0.05) of body weight , FCR and food (%)of intestinal weight /B.W, and D-xylose absorbance( %)which affected by colitis in T1and T2 .The analysis of the photomicrograph of jejunum revealed the beneficial effects of Lactobacillus acidophilus on the intestinal mucosa by increasing the length of villi and the lesser colitis damage . Conclusion: L. acidophillus administration was efficient in improve the intestinal physiology and morphology in experimentally induced colitis.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.