Abstract
Effects of lactisole on pancreatic islet B-cells electrophysiology
Highlights
Lactisole, a broad-acting sweet antagonist, suppresses the sweet taste of sugars, protein sweeteners and artificial sweeteners in human and other primates
The target for lactisole action in human subjects was identified as the sweet taste receptor TIR3 [1]
Taking into account these premises, lactisole was recently used as an antagonist of the sweet taste receptor in pancreatic islet B-cells in order to characterize the second messengers involved in the activation of the latter receptor [24]
Summary
A broad-acting sweet antagonist, suppresses the sweet taste of sugars, protein sweeteners and artificial sweeteners in human and other primates. The target for lactisole action in human subjects was identified as the sweet taste receptor TIR3 [1]. Taking into account these premises, lactisole was recently used as an antagonist of the sweet taste receptor in pancreatic islet B-cells in order to characterize the second messengers involved in the activation of the latter receptor [24]. It was recently reported that sucralose, known to mimic the effects of D-glucose upon several metabolic and functional variables in pancreatic islet B-cells [5,6,7,8], mimics the effect of the hexose upon B-cell electrical activity [9]. Experimental data are presented which document a more complex bioelectrical response than that expected of mice pancreatic islet B-cells to lactisole
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